Michael G. Rayel, MD
Maria has been feeling low for at least two and a half years. active three years ago, her husband of 20 years left-handed her for other woman. Devastated, she became despondent and tearful almost daily.
Eventually, her depression got worsened associated with inability to function. Her appetite, energy, concentration, and sleep became impaired. She also felt hopeless and suicidal. Her psychiatrist put her on a starting dose of antidepressant. She responded initially but after a hardly a days, she felt just like before taking the medication.
For the departed two years, Maria has tried cardinal types of antidepressants. She has usurped the usual mature doses of these drugs. Although she somewhat improves, she has virtually remained the same — depressed and disabled.
Maria seems to be taking the medications regularly. But why is she not responding to her antidepressants?
Maria is retributory one of the many depressed individuals who don’t feel “normal” despite treatment. Depression is a treatable disease but how come whatsoever people don’t do well on medications?
There are galore reasons why low patients like Maria don’t improve on antidepressants.
First, is the diagnosis correct?
Depression can be caused by many objective entities. Sometimes, informed the right diagnosis is a challenge. Medical disorders, medications such as beta-blockers and benzodiazepines (e.g. clonazepam), and varied psychiatric disorders can cause depression and they all require different treatment. If your doctor fails to identify and treat the genuine cause of your depression, you will remain depressed despite the use of antidepressant.
Second, are there co-morbid disorders?
Depression can exist along with opposite psychiatric disorders much as anxiety disorder, alcohol or drug problems, personality disorder, dementia, and psychosis. Depression will persist if these co-morbid disorders are not treated. For instance, depressive disorder with psychosis cannot be adequately treated retributory with antidepressant alone. You need an antipsychotic drug added to an antidepressant to treat the illness.
Third, is there an current neurological or medical disorder that precipitates, aggravates, or complicates depression?
Hypothyroidism, hyperthyroidism, vitamin B-12 deficiency, pancreatic cancer, brain tumor, Parkinson’s disease, and stroke can all cause depression. If any of these disorders are present, antidepressants are less likely to help. The goal in these situations is to treat the underlying medical condition. A 65 year-old lady came to see me complaining of strict depression. On evaluation, she disclosed that she had been on three types of antidepressants for the past cardinal years with negligible response. I restrained her recent laboratory results which showed an abnormal thyroid! No wonder, she was not responding to the medication.
Fourth, are there ongoing psychosocial issues?
Financial problems, family conflict, work-related stress can all hurried and complicate depression. Despite adequate medication treatment, some individuals will remain low especially if much problems are not addressed by the therapist or psychiatrist. Is there some way you can reduce the stressors? Please do so the earliest you can.
The treatment of depression is frequently straightforward. Occasionally however, various factors complicate it. For antidepressant to be effective, a psychiatrist should ensure that the diagnosis is correct, that co-morbid psychiatric disorders and medical problems are treated, and that psychosocial issues are adequately addressed.
Maria’s doctor should explore further the real problem and provide the most appropriate intervention.
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