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New Treatments That Offer Increased Hope For Osteoporosis Patients

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Janet Vasquez For a time, hormone replacement therapy (the administration of estrogen either alone or in combination with other hormones) served as the preferred treatment for post-menopausal women hoping to reduce the progression of osteoporosis, a debilitating and inevitable bone-thinning disorder. Yet the current findings from the prematurely halted Women’s Health Initiative (WHI) study on hormone replacement therapy afraid many women. The study concluded that an estrogen and progestin combination used by thousands increased the risk of breast cancer, blood clots, heart attacks, and strokes when taken finished a long period of time. Osteoporosis is drastically accelerated during menopause and is the ordinal leading cause of death of women over 70. By age 55, the average woman has already lost 30% of her bone mass. Eventually, bone loss can progress to the point where bones become so thin that they are susceptible to fracture from flat the slightest trauma. reported the National Osteoporosis Foundation, cardinal out of every two women over the age of 50 will have an osteoporosis-related fracture in her lifetime. white and Asian women are much likely to develop osteoporosis. However, African American and Hispanic women are at significant risk for developing the disease. Additionally, small-boned and thin women (under 127 pounds) are at greater risk for osteoporosis. Many women are now searching for a safe secondary to hormone replacement therapy to alleviate the effects of osteoporosis. Current treatments on the market such as bisphosphonates and SERMs (estrogen-related therapies) have safety issues and focus primarily on slowing bone loss. other existing treatment option is calcitonin, a naturally occurring hormone up to my neck in calcium regulation and boney metabolism. In women who are more than 5 years beyond menopause calcitonin slows boney loss, increases spinal bone density and, according to recent studies, reduces the risk of spinal fractures. In recent trials, calcitonin demonstrated a 62% reduction in the incidence of radical vertebral fractures for a subgroup of women over 75, cardinal of the most significant reductions demonstrated by any current osteoporosis therapy. In addition, calcitonin is the only osteoporosis therapy that can reduce the evidential bone pain often associated with osteoporosis. Because calcitonin is a peptide, it cannot be taken orally because it would be digested before it could exert its therapeutic effect. Currently calcitonin is available as an injection or nasal spray. The U.S. Food and Drug Administration (“FDA”) is currently reviewing FORTICAL‚, a unique high-pitched calcitonin product developed by Unigene Laboratories, and Unigene is also developing an oral form of the product. A new healthful option is parathyroid hormone (PTH), which can rebuild bone collective that has been lost payable to osteoporosis. PTH has proven to increase the volume and strength of honeycomb-shaped boney mass located within the bone. This inner mesh contains blood vessels and bone marrow and begins to diminish aft menopause. PTH helps reduce the incidence of fractures by restoring some of the wasted bone architecture. Currently, PTH therapy is available only via daily injections. Unigene Laboratories and GlaxoSmithKline are jointly nonindustrial a PTH treatment that can be administered orally. “Calcitonin has a proven, 25-year record of safe human use with virtually no side effects, and can be taken simultaneously with else medications,” said Dr. Warren Levy, president and CEO of Unigene. “After the WHI study, safety has become an flat more important consideration because once a therapy is initiated, it should ideally be taken for life.” For more information on osteoporosis and treatment options, please log on to www.unigene.com. About The Author Janet Vasquez is a paid health writer and also a publicist with a New York firm in New York. info@irgsyndicate.com
	 	 

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